Just use your anterior cingulate. Christopher Bergen at Scientific American:

Brassen and her colleagues found that for healthy older participants, the area of the brain which is usually active during the experience of regret, the ventral striatum, was much less active during rounds of the game where they missed out on a lot of money, suggesting that the healthily aging brains were not processing regret in the same way the young and depressed older brains were. Also, when they looked at the emotion controlling center of the brain, the anterior cingulate, the researchers found that this area was much more active in the healthy older participants than the other two groups. Interestingly, Brassen and her colleagues found that the bigger the missed opportunity, the greater the activity in this area for healthy older participants, which suggests that their brains were actively mitigating their experience of regret.

(H/T: The Hairpin)
 



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